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Chemistry

SERVICE AREAS & COMPETENCES

Service Areas

Hit-to-Lead Generation

  • Library Design
  • Focused Library/Parallel Synthesis
  • Leads property assessment

Lead Optimization & Preclinical Candidate Selection

  • Medicinal Chemistry/SAR Development
  • Integrated drug discovery projects
  • Candidate property assessment

Organic Synthesis

  • Intermediates, building blocks
  • Reference compounds synthesis
  • Metabolites and impurity synthesis
  • Route discovery, selection and development

Scale-up

  • Scale-up of intermediates, building blocks, drug candidates up to several hundred grams scale

Analytical Support

  • HPLC-MS, UPLC-MS and GC-MS
  • NMR: 400 MHz, 300 MHz
  • Semi-prep and Prep-HPLC (largest injection: 1g)
  • Mass-triggered prep-HPLC
  • Chiral separation: semi-prep scale chiral HPLC
  • SFC-80 system
  • Automatic Flash systems: multiple sets in labs

Core COMPETENCES

Large, experienced chemistry team (over 400 experienced chemists) which is one of the largest in China

Fully equipped analytical support and newly renovated labs that provide fast turnaround time

Seasoned management team with a wealth of experience gained from previous employment in the pharmaceutical and biotechnology industries

Seamless internal collaboration with our Biology, DMPK, and process departments to conduct integrated drug discovery programs

Successful track record and distinguished reputation from the world’s top 10 global biopharma firms. Has serviced more than 160 clients worldwide

Experienced in library design and delivered more than 60,000 library compounds and 1,000 building blocks