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Biology

SERVICE AREAS & COMPETENCES

SERVICE AREAS

IN VITRO DRUG HTS SCREENING

  • GPCR screening platform: function assay (cAMP, cGMP, Ca2+ flux, IP1, pH, Ion channels), binding assay
  • Kinase & enzyme assays with HTRF, LANCE, Z’-LYTE, LanthaScreen, FP, Alpha Screen, SPA
  • Immunotherapy drug screening: IDO, TDO inhibitor

MOLECULAR BIOLOGY

  • CRISPR genome editing services
  • Gene cloning, protein expression and purification, activity assay
  • Plasmid Construction and Lentivirus package
  • Mutagenesis, QPCR, ELISA, Western blotting, IP, etc

CELL BIOLOGY

  • Cell-based assays: MTS, soft agar, colony formation, FACS - cell cycle analysis, apoptosis, tube formation, migration/invasion
  • Stable cell lines (over expression, knock down, knock out)
  • Drug-resistant cell lines

IN VIVO PHARMACOLOGY STUDY

  • Oncology
    • >160 Tumor Cell lines
    • >60 Xenograft tumor models
    • >10 Syngenic tumor models
  • Neuroscience
    • Parkinson’s Disease
    • Neuropathic Pain Model
    • Learning & Memory
    • Depression & Anxiety
    • Metabolism and Inflammation
    • Metabolic Disease
    • Arthritis
    • Acute inflammation

Core COMPETENCES

Experience in vitro drug screening with powerful instruments

Immunotherapy drug screening service for IDO, TDO inhibitor

More than 120 kinase/enzyme assay platform

Experience in customized animal models

Animal models covering a wide range of therapeutic areas

SPF animal facility with extensive audit records

BSL level II certified facility

Fully integrated service platform with a DMPK team that provides seamless discovery and pre-clinical service